Population continuity and ghost genetic ancestries in pre-Hispanic Mexico. Ancient individuals who inhabited the northern frontier of Mesoamerica (NFM) before and after a 200-year period of severe droughts (shown in timeline) belong to a continuous population. This is in contrast to a previous hypothesis suggesting that hunter-gatherers from Aridoamerica replaced the populations at the NFM following the southward shift of its limits with Mesoamerica (solid and dashed lines). Individuals from Sierra Tarahumara and Cañada de la Virgen show genetic ancestry from two distinct ghost populations (UpopA and UpopA2).